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. 2018 Mar 8;8:4189. doi: 10.1038/s41598-018-22635-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of HSP27 inhibitor on gross morphology and histopathological analysis. (A) Representative gross finding. Mice were sacrificed at two weeks after irradiation. Four-percent paraformaldehyde was instilled via trachea, and lungs were immersed in fixation solution and photographed after complete fixation. (B) Haematoxylin and eosin-stained lung sections. Numbers 1 and 2 indicate areas of radiation-induced injury and spread of inflammation toward outside of radiation-induced injury. Magnification, 10×, 400×. (C) Quantification of inflammatory score. (D) Thickness of bronchiolar epithelium. Results are expressed as mean ± standard error. ***P < 0.001, versus control; ^#P < 0.05 and ^##P < 0.01 versus IR. Control, untreated; IR, 75 Gy irradiation (IR); IR + J2, irradiation + 15 mg/kg J2; IR + AMI, irradiation + 100 mg/kg amifostine; J2, 15 mg/kg J2 only and AMI, 100 mg/kg amifostine only.