Table 1.

MICs of SMX, TMP, and MAC173979 and FICI_m of SMX-TMP and MAC173979-TMP

Bacterial strains	MIC (µg ml–1)			FICIm
	SMX	TMP	MAC173979	SMX-TMP	MAC173979-TMP
E. coli BW25113	1.6	0.60	1.6	0.31	0.63
E. coli B11	3.1	1.0	0.80	0.31	1.0–2.0
S. aureus USA300	0.80	0.50	6.3	0.16	1.0

FICI_m, minimum fractional inhibitory combination of antimicrobial agent pairs found to achieve growth inhibition; MIC, minimum concentration of antimicrobial agent required to inhibit at least 50% of growth relative to a no drug control after 24 h of incubation at 37 °C; SMX, sulfamethoxazole; TMP, trimethoprim