Fig. 2. (a-c) Measured vs. predicted values for drug-patiromer binding derived from QSPR equations.

Both the model (training set), and leave-one-out cross-validation set (CV set) are plotted, along with the best-fit line to the training set for each buffer. AB, acetate buffer; CV, cross-validation; QSPR, quantitative structure-property relationship; SGF, simulated gastric fluid; SIF, simulated intestinal fluid.