Table 2. Logistic regression analysis of associations between HIF1A rs10873142 polymorphism and risk of COPD.
| Genotype | Cases* (n=235) | Controls* (n=548) | OR (95% CI) | P | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| CT compared with CC | 111/80 | 47.2/34.0 | 246/227 | 44.9/41.4 | 1.28 (0.91–1.80) | 0.153 |
| TT compared with CC | 39/80 | 16.6/34.0 | 68/227 | 12.4/41.4 | 1.63 (1.02–2.60) | 0.042 |
| TT + CT compared with CC | 150/80 | 63.8/34.0 | 314/227 | 57.3/41.4 | 1.36 (0.98–1.87) | 0.063 |
| TT compared with CT + CC | 39/191 | 16.6/81.2 | 68/473 | 12.4/86.3 | 1.42 (0.93–2.18) | 0.108 |
| T compared with C | 189/271 | 40.2/57.7 | 382/700 | 34.9/63.9 | 1.29 (1.02–1.60) | 0.032 |
Bold values are statistically significant (P<0.05).
*
The genotyping was successful in 230 cases and 541 controls.