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. 2016 Mar 21;1:3. doi: 10.1186/s41181-016-0005-5

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — [¹⁸F]JNJ42259152 BP_ND values after a 5-days amphetamine treatment. Left: Transversal images of PDE10A binding in brain. Images are overlaid on a VOI map and presented as averaged, parametric BP_ND images (Logan Reference) at baseline conditions (a), at day 5 (b) and day 15 (c) of the experiment. Right: Averaged (d) and individual (e) BP_ND values in striatum of amphetamine treated rats at baseline conditions, after 5 days of amphetamine treatment (day 5) and after 10 days of washout (day 15). Each line represents a repeated measurement in a single rat at different stages of treatment. Averaged data are presented as mean ± SD. Wilcoxon matched pair test; *p < 0.05