Table 1.
Overview of the different treatment groups (* saline treatment, equivalent volumes)
| Experiment | Treatment | Injection route | Dose (mg/kg) | Duration of treatment | Time before scan | n |
|---|---|---|---|---|---|---|
| 1 | Amphetamine | SC | 5 | Acute | 60 min | 6 |
| 2 | Amphetamine | IV | 1 | Acute | 5 min | 5 |
| 3 | Saline (test/retest) | SC | * | Acute | 60 min | 3 |
| 4 | Saline (test/retest) | IV | * | Acute | 5 min | 3 |
| 5 | Amphetamine | SC | 5 | 5 days | 4 h | 5 |
| 6 | Amphetamine + SCH23390 |
SC | 5 1 |
5 days | 4 h | 6 |
| 7 | SCH23390 | SC | 1 | 5 days | 4 h | 5 |
| 8 | Saline | SC | * | 5 days | 4 h | 3 |
Rats undergoing acute treatment were scanned at baseline conditions and after acute treatment. The 5 day treatment consisted of a baseline scan, a scan immediately after the 5 day treatment and a scan 10 days after the last treatment