Scheme 1.
Synthesis of DOTAZOL: (i) benzyl bromoacetate, DMF, Cs2CO3, 0 °C, 12 h. (ii) H2, Pd/C, MeOH, RT, 24 h. (iii) 1. PCl3 ,H3PO3, MeSO3H, 75 °C, 12 h, 2. H2O, 105 °C, 24 h. (iv) DOTA-NHS-ester, Na2CO3, 40 °C, 24 h
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.