Table 2. Variants of uncertain significance in complement and coagulation genes predicted to not be deleterious by some or all prediction methods.

Gene	Patient	AA change	Nucleotide	dbSNP ID	In-silico prediction
C1S	14	p.K210T	c.629 A>C	rs782009231	Mixed
C2	15	p.N310S	c.929 A>G	rs144201432	All predict benign
C2	16	p.P724L	c.2171C>T	rs145050210	All predict benign
C3	17	p.K155Q	c.463 A>C	rs147859257	All predict benign
C3AR1	18	p.S308A	c.922 T>G	rs757235303	All predict benign
C8A	19	p.R485L	c.1454_1455delGCinsTT	rs386631447	Mixed
C8A	15	p.D129N	c.385G>A	rs150404785	Mixed
C9	20	p.D80N	c.238G>A	rs115196369	All predict benign
CD46	21	p.R82W	c.244C>T	rs200133631	Mixed
CFB	22	p.I242L	c.724 A>C	rs144812066	Mixed
CFB	17	p.S284N	c.851G>A	rs756948669	All predict benign
CFH	17	p.Q950H	c.2850G>T	rs149474608	Mixed
CFH	23	p.R166L	c.497G>T	None	Mixed
CFH	24	Splice site	c.3134-5 T>A	rs513699	Mixed
CFH	25	p.P43T	c.127C>A	rs764941928	All predict benign
CFH	26	p.T956M	c.2687C>T	rs145975787	All predict benign
CFHR4	27	p.Y362H	c.1084 T>C	rs201636212	Mixed
CFHR4	28	p.W233C	c.699G>C	rs116119247	Mixed
CFHR4	29	p.Y35H	c.103 T>C	rs138792300	Mixed
CFHR4	4	p.L561I	c.1681C>A	rs80010185	All predict benign
CFHR5	30	p.C568Ter	c.1704 T>A	rs143140599	Mixed
CFHR5	31	p.G471E	c.1412G>A	rs144438200	Mixed
CFI	32	p.K267E	c.799 A>G	rs75612300	Mixed
CFI	33	p.I416L	c.1246 A>C	rs61733901	Mixed
CFI	34	p.H183R	c.548 A>G	rs75612300	Mixed
CR2	20	p.V946M	c.2836G>A	rs147451324	Mixed
CR2	35	p.R428H	c.1283G>A	rs183067414	Mixed
CR2	36	Splice site	c.2903-3C>A	rs372214909	All predict benign
CR2	37	p.S1016L	c.3047C>T	rs138062179	All predict benign
MASP1	2	p.R288Q	c.863G>A	rs116001173	Mixed
MASP1	38	p.R441H	c.1322G>A	rs141872329	Mixed
PLG	39	p.T742N	c.2225C>A	None	Mixed
PLG	40	Splice site	c.407+8 A>G	None	All predict benign
PLG	22	p.D258N	c.772G>A	rs138242513	All predict benign