Table 1. IC50 values (μmol/L) of naturally occurring pentacyclic triterpenes and ursolic acid derivatives for the inhibition of USP7 in vitro.
Compd | Name | IC50 (μmol/L) |
---|---|---|
1 | Ursolic acid | 7.0±1.5 |
2 | Corosolic acid | 22.7±2.1 |
3 | Asiatic acid | NAa |
4 | Madecassic acid | NAa |
5 | Oleanolic acid | 12.5±1.0 |
6 | Hederagenin | 33.5±1.0 |
7 | Bayogenin | NAa |
8 | Polygalacic acid | NAa |
9 | Pristimerin | 21.1±3.2 |
10 | Glycyrrhetic acid | NAa |
11 | Senegenin | NAa |
12 | Lupeol | NAa |
13 | Betulinic acid | 33.3±2.6 |
14 | — | NAa |
15 | — | NAa |
aNA=no activity (IC50 >50 μmol/L).