Table 1. Estimated pharmacokinetic parameters of DEX in nude mice at 8 mg·kg−1·d−1.
| Parameters | Typical estimates | 95% CI | IIV |
|---|---|---|---|
| Ka (h−1) | 1.95 | 0.47–2.48 | 0 FIX |
| CL/F (L/kg·h−1) | 1.28 | 1.03–1.41 | 0 FIX |
| Vc/F (L/kg) | 2.47 | 1.08–2.93 | 0 FIX |
| Vp/F (L/kg) | 4.87 | −0.46–10.85 | 0 FIX |
| Q/F (L/kg·h−1) | 1.34 | 0.68–1.59 | 0 FIX |
| Emax | 1.09 | 0.97–1.84 | 0 FIX |
| ET50 (h) | 81.3 | 71.68–151.54 | 0 FIX |
| γ | 4.38 | 1.25–6.48 | 0 FIX |
| ωIOV1 (CV%) | 26.8% | ||
| ωIOV2 (CV%) | 217.7% | ||
| Residual errors | |||
| σprop (%) | 33% | ||
| σadd (ng/mL) | 0.01 |
CI, confidence interval; IOV, inter-occasion variability; IIV, inter-individual variability; CV, coefficient variation.