Table 2. Estimated pharmacodynamic parameters of the integrated PK/PD model.
Parameters | Typical estimates | RES% | IIV (CV%) |
---|---|---|---|
λ0 (h−1) | 0.0065 | 8.9 | 0 FIX |
λ1 (mm3·h−1) | 28.1 | 28.6 | 21.1 |
ω0 (mm3) | 42 | 7.1 | 26.3 |
EC50 (ng/mL) | 48.5 | 22.1 | 70.1 |
Residual errors | |||
σprop (%) | 10.9% | ||
σadd (mm3) | 27.0 |
RSE, relative standard error; IIV, inter-individual variability; CV, coefficient variation.