Table 3.
Association of AGT genotypes with PE.
| SNP | Genotype | PE cases | Controls | p | OR (95% CI) | p | aORb (95% CI) |
|---|---|---|---|---|---|---|---|
| M235T | MM | 137 (0.50)a | 176 (0.63) | 0.003 | 1.00 (reference) | 0.006 | 1.00 (reference) |
| MT | 109 (0.40) | 90 (0.32) | 1.56 (1.09–2.22) | 1.79 (1.18–2.71) | |||
| TT | 26 (0.10) | 12 (0.04) | 2.78 (1.36–5.72) | 2.43 (1.05–5.63) | |||
| T147M | TT | 196 (0.89) | 167 (0.82) | 0.015 | 1.00 (reference) | 0.031 | 1.00 (reference) |
| TM | 22 (0.10) | 37 (0.18) | 0.51 (0.29–0.89) | 0.49 (0.25–0.96) | |||
| MM | 2 (0.01) | 0 (0.00) | NA | NA |
a
Number (frequency).
b
aOR: adjusted OR, adjusted for body mass index, gestation, and baby weight.
AGT: angiotensinogen; PE: preeclampsia; SNP: single-nucleotide polymorphism; T: threonine; M: methionine; OR: odds ratio; CI: confidence interval.