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. 2016 Oct 26;17(4):1470320316673231. doi: 10.1177/1470320316673231

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Longitudinal changes of renal function. Fasting serum urea, albumin, creatinine and urine total protein to creatinine were measured in sham, uninephrectomised (UNX), angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) rats at 3, 6 and 9 months after uninephrectomy. There were no statistical differences in fasting serum urea, albumin and creatinine among the four groups at 3 and 6 months, but in the ratio of total protein to creatinine. Uninephrectomised rats had higher serum urea (a), creatinine (b) and urine total protein to creatinine ratio (d), but lower albumin (c) than that of the sham group, and treatments with ACEI and ARB corrected the abnormal fasting serum levels close to the sham group at 9 months and attenuated the urine ratio during the whole detection. Data are mean±SD. ^†P<0.05, uninephrectomised rats versus sham rats; ^#P<0.05, uninephrectomised rats versus ACEI rats; ^§P<0.05, uninephrectomised rats versus ARB rats.