Table 3. Independent prognostic value of the accumulation of driver alterations for TTFT.

Variable	HR (95% CI)	P-value
Binet stage (B/C vs A)	2.44 (1.60–3.74)	<0.001
No. drivers (0, 1, 2, 3, ⩾4)	1.44 (1.21–1.72)	<0.001
SF3B1 (mut vs unmut)	2.02 (1.39–2.94)	<0.001
IGHV (unmut vs mut)	2.07 (1.35–3.19)	0.001
ATM (mut/deletion vs wt)	1.82 (1.19–2.27)	0.006
Age at sampling (>65 vs ⩽65 years)	0.66 (0.48–0.91)	0.011

N=307, events=146, competing events=27. Starting model: IGHV, Binet stage, age at sampling, gender, TP53 aberration (mutation/deletion), ATM aberration (mutation/deletion), SF3B1 mutation and number of driver alterations (not including TP53, ATM and SF3B1 mutations, neither del(17p) nor del(11q)).