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. 2018 Jan 5;32(3):846–849. doi: 10.1038/leu.2017.324

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Ibrutinib inhibits RAC1 activation and sensitized cells for NSC23766 treatment in MA9.3 cells. (a) MA9.3 cells were treated with ibrutinib (IBR) (2 μm) for 14 h. GTP-RAC1 was enriched and detected using active GTP-RAC1 activation assay. Bound RAC1 and total RAC1 (upper and lower blots) were detected using RAC1 antibody (left). RAC1-GTP protein was densitometrically quantified. Percentage of RAC1 activation from four independent experiments is shown (right). (b) Control and MA9.3 cells were treated with DMSO or NSC23766 (NSC) or ibrutinib (IBR) as indicated for 48 h and assayed for cell viability. Percentage of viable cells from four independent experiments is shown. Error bars indicate s.e.m. *P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001.