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. 2017 Aug 16;18(3):1470320317717883. doi: 10.1177/1470320317717883

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Mean cortisol (a) and 11-deoxycortisol (b) concentrations (over 24 hr) at steady state. Plasma samples collected at pre-dose, 4 hr, 12 hr, 24 hr post-dose on Day 7. C_ave calculated as AUC(0-24) divided by 24hr. Mean change from pre-challenge plasma cortisol (c) and 11-deoxycortisol (d) after IV ACTH challenge. IV ACTH challenge was conducted 1 hr post-dose on Day 8. Steroids measured at -15 mins (baseline), 30 mins and 60 mins post-challenge. C_ave calculated as baseline subtracted AUC(0-1hr) divided by 1hr. Box and whiskers plots: mean(dot); median (center line within box); 25th and 75th percentiles as edges of the box; whiskers extends as far as the data extend to a distance of at most 1.5 interquartile range (IQR); Outliers (data points outside of ± 1.5 IQR) are presented as stars (*).