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. 2017 Oct 24;32(3):736–743. doi: 10.1038/leu.2017.287

Figure 1.

Figure 1

JAM-A is overexpressed in MM patient-derived primary plasma cells. (a) MM primary plasma cells (MM-PCs): May–Giemsa and immunofluorescence staining of JAM-A expression from a representative patient. Scale bar, 10 μm. (b) FACS analysis of cell JAM-A surface expression from representative patient-derived, immunoselected MM-PCs, gated on live cells, identified as CD138+ cells. Red and dark blue curves indicate isotype staining and unstained controls. (c) Representative patients with low versus high JAM-A level (FACS). (d) Patients with low expression had a better PFS than patients with high JAM-A expression (log-rank test—left panel). Detailed information for PFS of patients with JAM-A surface expression (right panel). For 5 out of 147 patients JAM-A surface expression was unobtainable and for 1 patient complete information regarding date of disease progression and death was not available.