Figure 2.

JAM-A is overexpressed in bone marrow biopsies of MM patients. JAM-A immunohistochemical staining of BM trephines from a single representative MM patient (at t0, t1 and t2) compared with MGUS control. Depending on the disease stage, different JAM-A expression patterns become overt: weak JAM-A staining in MGUS samples, JAM-A expression detectable at the time of recruitment in NDMM, weak after therapy but even stronger at disease relapse. MGUS Pt=MGUS-patient, NDMM=newly diagnosed MM patient. t0=at the time of recruitment; t1=after treatment; t2=at disease relapse. Original magnification × 200, scale bar, 50 μm.