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. Author manuscript; available in PMC: 2018 Mar 9.

Published in final edited form as: Behav Genet. 2011 Sep 11;42(2):299–312. doi: 10.1007/s10519-011-9501-2

Table 1.

Review of Mecp2 in social behaviour


Mutant	Region/Cell	Background	Reduced/Impaired	Reference
MeCP2^308/y	Constitutive Truncation	129SvEv or 129SvEv × C57BL/6J	Tube Test Avoidance	Shahbazian et al. 2002
MeCP2^308/y	Constitutive Truncation	129/SvEv	Tube Test Avoidance; Nest Building; Divided Homecage Proximity; Interaction with Unfamiliar Juvenile	Moretti et al. 2005
MeCP2^CKO	Forebrain Conditional	B6	Divided Homecage Proximity	Gemelli et al. 2006
Rat siRNA	Amygdala	Sprague Dawley	Juvenile Play	Kurian et al. 2008
Mecp2^Flox/y	CNS-Conditional Flanked Hypomorph	129S6/B6	Nest Building	Samaco et al. 2008
MeCP2^308/y	Constitutive Truncation	B6	USVs Maternal Separation	De Fillipis et al. 2010
MeCP2^CKO	GABA Neurons	129;FVB	Nest Building	Chao et al. 2010

Mutant	Region/Cell	Background	Increased/Enhanced	Reference

MeCP2^lox/y	Constitutive Flanked Hypomorph	129S1/SvImJ;B6/CBA	Three Chamber Social Preference and Novelty Preference	Kerr et al. 2008
Mecp2^Flox/y	CNS-Conditional Flanked Hypomorph	129S6/B6	Proximity in Partition Test	Samaco et al. 2008
MeCP2^flox/+, and MeCP2^CKO	Flanked WT, and Hypothalamus	129SvEV/B6	Proximity in Partition Test^#	Fyffe et al. 2008
MeCP2^flox/y, and MeCP2^CKO	Flanked WT, DA/NE- and 5-HT-Neurons	129S6SvEV (flox), 129;FVB (DA/NE), 129;B6 (5-HT)	Proximity in Partition Test^#	Samaco et al. 2009
MeCP2^flox, and MeCP2^CKO	Flanked WT, GABA-, and FB GABA Neurons	129S6SvEV (flox), 129;FVB (GABA)	Proximity in Partition Test; Three-Chamber Social Preference	Chao et al. 2010
MeCP2^1lox	CNS-Conditional	B6	Three-Chamber Social Preference and Social Novelty Preference	Schaevitz et al. 2010

^#

Signifies accompanying aggression in mutant