Table 1.
miRNA | Expression during liver regeneration | Target(s) | Model | Effect of miRNA | Citation |
---|---|---|---|---|---|
miR-23b | downregulated at termination phase | SMAD3 | Rats | Inhibition of miRNA inhibited liver cell proliferation | [135] |
miR-26a | downregulated | Cyclin D2*, Cyclin E2* | Mice | Inhibition of miRNA promotes hepatocyte proliferation | [136] |
miR-127 | downregulated | BCL2*, SETD8* | Rats | Inhibition of miRNA promoted liver cell proliferation | [137] |
miR-221 | upregulated | p27, p57, Arnt, Puma | Mice | Overexpression of miRNA promoted hepatocyte proliferation | [138–140] |
miR-382 | upregulated | PTEN | Mice, humans | Overexpression of miRNA promoted liver cell proliferation | [141, 142] |
Asterisk (*) represents that only correlation between miRNA and target was shown, not direct interaction.