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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Arch Toxicol. 2017 May 13;91(8):2781–2797. doi: 10.1007/s00204-017-1974-1

Table 1.

Additional miRNAs involved in in vivo liver regeneration

miRNA Expression during liver regeneration Target(s) Model Effect of miRNA Citation
miR-23b downregulated at termination phase SMAD3 Rats Inhibition of miRNA inhibited liver cell proliferation [135]
miR-26a downregulated Cyclin D2*, Cyclin E2* Mice Inhibition of miRNA promotes hepatocyte proliferation [136]
miR-127 downregulated BCL2*, SETD8* Rats Inhibition of miRNA promoted liver cell proliferation [137]
miR-221 upregulated p27, p57, Arnt, Puma Mice Overexpression of miRNA promoted hepatocyte proliferation [138140]
miR-382 upregulated PTEN Mice, humans Overexpression of miRNA promoted liver cell proliferation [141, 142]

Asterisk (*) represents that only correlation between miRNA and target was shown, not direct interaction.