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. 2018 Feb 15;15(4):5959–5965. doi: 10.3892/ol.2018.8058

Figure 4.

Figure 4.

SREBP1 facilitates the binding of c-Myc to the SNAIL promoter. (A) qPCR analysis of the expression of c-Myc in different CRC cell lines and a normal cell line. Data are presented as the mean ± standard deviation of three independent experiments. ***P<0.001 vs. scramble or control. (B) Co-IP of SREBP1 and c-Myc in CRC cells transfected with SREBP1 and c-Myc. (C) ChIP-qPCR analysis of the binding of c-Myc on the SNAIL promoter in CRC cells transfected with SREBP1. Data are presented as the mean ± standard deviation of three independent experiments. ***P<0.001 vs. control. (D) ChIP-qPCR analysis of the binding of c-Myc to the SNAIL promoter in CRC cells transfected with SREBP1 siRNA and scramble siRNA. Data are presented as the mean ± standard deviation of three independent experiments. ***P<0.001 vs. scramble. SREBP1, sterol regulatory element-binding protein 1; qPCR, quantitative polymerase chain reaction; CRC, colorectal cancer; Co-IP, co-immunoprecipitation; ChIP, chromatin immunoprecipitation; siRNA, small interfering RNA; IgG, immunoglobulin G.