Figure 1.

Enrichment for specific glycans to EVs.

Lectin microarrays have shown that EVs are preferentially enriched in certain glycan features compared to more diverse glycan repertoire of the producing cell membranes [38,39]. These features include polylactosamine and α2-6 linked sialic acid residues, and high mannose and complex type N-glycans. Exclusion of blood group A/B antigens was also identified. Glycans of this figure are representative of these features but are not definitive structures as these are not possible to obtain through lectin microarrays alone.