Figure 6.

TCR-transduced CD8+ T cells inhibit tumor growth in vivo. MCF-7 cells (5×10⁶) were inoculated subcutaneously into 15 BALB/c-nu mice to establish a subcutaneous transplant tumor model. When tumors reached a mean volume of 150 mm³, the mice underwent intravenous tail vein transplantation with either normal saline, 1×10⁷ PLAC1 TCR-transduced CD8+ T cells or NC-transduced CD8+ T cells twice with a 1-week interval. The tumors were measured once/week using electronic calipers. The longest length and width were recorded, and the tumor volume was calculated according to the formula (π/6) (length) × (width)². *P<0.05 compared with the TCR (PLAC1) group, with comparisons shown by lines. TCR, T cell receptor; CD8+ T cells, cytotoxic T cells; PLAC1, placenta-specific 1; NC, negative control.