Table IV.
Toxicity grades of patients in the two groups from the matched dataset.
No. of patients (%) | ||||
---|---|---|---|---|
Chemotherapy-bevacizumab (n=38) | Chemotherapy alone (n=38) | |||
Toxicity | Grade 1/2 | Grade ≥3 | Grade 1/2 | Grade ≥3 |
Hematological toxicity | ||||
Leukopenia | 14 (36.8) | 5 (13.2) | 11 (28.9) | 4 (10.5) |
Neutropenia | 11 (28.9) | 3 (7.9) | 9 (23.7) | 4 (10.5) |
Anemia | 15 (39.5) | 0 (0.0) | 12 (31.6) | 1 (2.6) |
Thrombocytopenia | 6 (15.8) | 1 (2.6) | 7 (18.4) | 2 (5.3) |
Non-hematological toxicity | ||||
Increased ALT or AST | 15 (39.5) | 2 (5.3) | 13 (34.2) | 1 (2.6) |
Fatigue | 14 (36.8) | 2 (5.3) | 12 (31.6) | 0 (0.0) |
Nausea | 12 (31.6) | 0 (0.0) | 15 (39.5) | 1 (2.6) |
Vomiting | 7 (18.4) | 0 (0.0) | 7 (18.4) | 1 (2.6) |
Rash | 4 (10.5) | 0 (0.0) | 3 (7.9) | 0 (0.0) |
Joint or muscle pain | 4 (10.5) | 0 (0.0) | 1 (2.6) | 0 (0.0) |
Hypertension | 6 (15.8) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Bleeding | 15 (39.5) | 0 (0.0) | 2 (5.3) | 0 (0.0) |
Proteinuria | 4 (10.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
ALT, alanine transaminase; AST, aspartate transaminase.