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. 2018 Feb 15;15(4):5671–5679. doi: 10.3892/ol.2018.8064

Table IV.

Toxicity grades of patients in the two groups from the matched dataset.

No. of patients (%)

Chemotherapy-bevacizumab (n=38) Chemotherapy alone (n=38)


Toxicity Grade 1/2 Grade ≥3 Grade 1/2 Grade ≥3
Hematological toxicity
  Leukopenia 14 (36.8) 5 (13.2) 11 (28.9) 4 (10.5)
  Neutropenia 11 (28.9) 3 (7.9) 9 (23.7) 4 (10.5)
  Anemia 15 (39.5) 0 (0.0) 12 (31.6) 1 (2.6)
  Thrombocytopenia 6 (15.8) 1 (2.6) 7 (18.4) 2 (5.3)
Non-hematological toxicity
  Increased ALT or AST 15 (39.5) 2 (5.3) 13 (34.2) 1 (2.6)
  Fatigue 14 (36.8) 2 (5.3) 12 (31.6) 0 (0.0)
  Nausea 12 (31.6) 0 (0.0) 15 (39.5) 1 (2.6)
  Vomiting 7 (18.4) 0 (0.0) 7 (18.4) 1 (2.6)
  Rash 4 (10.5) 0 (0.0) 3 (7.9) 0 (0.0)
  Joint or muscle pain 4 (10.5) 0 (0.0) 1 (2.6) 0 (0.0)
  Hypertension 6 (15.8) 0 (0.0) 0 (0.0) 0 (0.0)
  Bleeding 15 (39.5) 0 (0.0) 2 (5.3) 0 (0.0)
  Proteinuria 4 (10.5) 0 (0.0) 0 (0.0) 0 (0.0)

ALT, alanine transaminase; AST, aspartate transaminase.