. 2018 Mar 9;16:37. doi: 10.1186/s12916-018-1014-x

Table 2.

Multivariate analysis (logistic regression model) of clinical and laboratory factors at admission associated with mortality at 72 h of randomisation

	Categories	Adjusted OR of death (95% CI)	p value^a
Age (months)	≥ 12	1.00 (Ref.)^b	< 0.01
Age (months)	< 12	1.98 (1.22, 3.2)	< 0.01
Gender	Male	1.00 (Ref.)^b	0.96
Gender	Female	1.01 (0.71, 1.46)	0.96
Site	Mbale	1.00 (Ref.)^b
	Kilifi	1.56(0.76, 3.23)	0.23
	Mulago	1.47 (0.80, 2.70)	0.21
	Soroti	1.16 (0.64, 2.14)	0.63
	Lacor	–	–
	Teule	2.04 (0.87, 4.76)	0.10
Lactate stratum (mmol/L)	No (< 2.5)	1.00 (Ref.)^b
	Moderate (2.5–5)	1.28 (0.62, 2.63)	0.50
	Severe (≥ 5)	6.96 (3.52, 13.76)	< 0.001
Level of consciousness	Alert	1.00 (Ref.)^b
	Prostration	1.41 (0.72, 2.76)	0.31
	Coma	6.87 (3.36, 14.04)	< 0.001
BUN (mmol/L)^d	< 7.14	1.00 (Ref.)^b	< 0.001
BUN (mmol/L)^d	≥ 7.14	2.92 (1.84, 4.62)	< 0.001
Malaria	No	1.00 (Ref.)^b	< 0.001
Malaria	Yes	0.45 (0.29, 0.69)	< 0.001
Severe anaemia (Hb < 5 g/dL)	No	1.00 (Ref.)^b	0.37
Severe anaemia (Hb < 5 g/dL)	Yes	0.81 (0.50, 1.29)	0.37
Hyperglycaemia^c (glucose ≥ 8.3 mmol/L)	No	1.00 (Ref.)²	0.55
Hyperglycaemia^c (glucose ≥ 8.3 mmol/L)	Yes	0.84 (0.55, 1.30)	0.55
HIV	No	1.00 (Ref.)²	0.05
HIV	Yes	2.16 (1.01, 4.60)	0.05

^aWald test p values

^bRef: Reference group

^cModerate evidence of interaction, stratum-specific odds ratios are shown in Additional file 1

^dBlood Urea Nitrogen