Table 3.
Lactate clearances within first 8 h of randomisation in survivors and non-survivors at 72 h
| Survivors | Non-survivors | Total | Unadjusted OR of death (95% CI) | p valuea | |
|---|---|---|---|---|---|
| Lactate clearance at 8 h amongst children with an abnormal lactate on admission ≥ 2.5 mmol/Lb | |||||
| Number, N (%) | 1792 (94) | 114 (6) | 1906 | – | – |
| Lactate at 8 h (mmol/L); median (IQR)c | 3.3 (2.3, 5) | 5.4 (3.4, 10) | 3.4 (2.3, 5.1) | – | < 0.001d |
| Absolute LC (mmol/L); median (IQR)c | 1.7 (0.2, 4.5) | 1.3 (−0.5, 4.7) | 1.6 (0.1, 4.6) | – | 0.12d |
| Relative LC (%); median (IQR)c | 37 (3.7, 59.5) | 17 (−6, 51) | 36 (3.33, 59) | – | 0.003d |
| Relative LC < 10% | 516/1792 (29) | 50/114 (44) | 566/1906 (30) | 1.93 (1.31, 2.84) | < 0.001 |
| Relative LC ≥ 40% | 840/1792 (47) | 38/114 (33) | 878/1906 (46) | 0.57 (0.38, 0.85) | < 0.01 |
| Lactate normalisatione | 540/1792 (30) | 14/114 (12) | 554/1906 (29) | 0.33 (0.18, 0.57) | < 0.001 |
| Relative LC ≥ 40% and/or lactate normalisation | 973/1792 (54) | 41/114 (36) | 1014/1906 (53) | 0.47 (0.32, 0.70) | < 0.001 |
| Lactate clearance at 8 h amongst those with lactate on admission ≥ 5 mmol/Lf | |||||
| N (%) | 919 (92) | 85 (8) | 1004 | – | – |
| Lactate at 8 h; median (IQR)c | 3.9 (2.7, 6) | 6.8 (4.1, 11.3) | 4.1 (2.8, 6.3) | – | < 0.001d |
| Absolute LC (mmol/L); median (IQR)c | 4.4 (2.4, 7.7) | 2.3 (0, 5.8) | 4.3 (2.3, 7.6) | – | < 0.001d |
| Relative LC (%); median (IQR)c | 55 (32, 71) | 23 (0, 62) | 54 (28, 70) | – | < 0.001d |
| Relative LC < 10% | 116 /919(13) | 33/85 (39) | 149/1004 (15) | 4.40 (2.70, 7.16) | < 0.001 |
| Relative LC ≥ 40% | 628/919 (68) | 33/85 (39) | 661/1004 (66) | 0.29 (0.18, 0.47) | < 0.001 |
| Lactate normalisatione | 200/919 (22) | 6/85 (7) | 206/1004 (21) | 0.27 (0.12, 0.64) | 0.001 |
| Relative LC ≥ 40% and/or lactate normalisation | 628/919 (68) | 33/85 (39) | 661/1004 (66) | 0.29 (0.18, 0.47) | < 0.001 |
aChi-squared test p values
bTotal of 811 children with normal lactate levels on admission (< 2.5 mmol/L) excluded
cRef: Reference group
dWilcoxon rank-sum test p values
eLactate decline < 2.5 mmol/L in the first 8 h after randomisation
f1713 children with lactate levels on admission < 5 mmol/L excluded