Table 2.
Baseline clinical and biochemical characteristics according to subsequent development of CVD in PCOS OUH
| Development of CVD | P# | ||||
|---|---|---|---|---|---|
| Yes N = 264 |
No N = 895 |
||||
| Baseline characteristics | N (%) | Median (Q1–Q3) | N (%) | Median (Q1–Q3) | |
| Age (years) | 230 (100) | 35 (28–39) | 935 (100) | 27 (21–33) | < 0.001 |
| BMI (kg/m2) | 245 (93) | 30.2 (25.1–35,2) | 831 (93) | 26.1 (22.6–31.1) | < 0.001 |
| Waist (cm) | 134 (51) | 100 (84–110) | 587 (66) | 87 (77–100) | < 0.001 |
| Systolic BP (mmHg) | 148 (56) | 130 (120–140) | 624 (70) | 123 (114–131) | 0.002 |
| Diastolic BP (mmHg) | 148 (56) | 85 (78–92) | 650 (70) | 80 (70–86) | < 0.001 |
| LDL cholesterol (mmol/L) | 184 (70) | 3.2 (2.6–3.9) | 663 (74) | 2.6 (2.1–3.1) | 0.275 |
| HDL cholesterol (mmol/L) | 186 (70) | 1.3 (1.1–1.6) | 663 (74) | 1.4 (1.1–1.6) | < 0.001 |
| Cholesterol (mmol/L) | 186 (70) | 5.2 (4.5–5.9) | 674 (75) | 4.5 (4.0–5.1) | < 0.001 |
| Triglycerides (mmol/L) | 186 (70) | 1.3 (0.9–1.9) | 662 (74) | 1.0 (0.7–1.3) | 0.026 |
| Prolactin (µg/L) | 223 (85) | 6 (5–9) | 731 (82) | 7 (5–10) | 0.010 |
| HbA1c (mmol/mol) | 108 (41) | 37 (33–42) | 463 (52) | 33 (31–37) | 0.298 |
| Fasting blood glucose (mmol/L) | 150 (57) | 4.7 (4.2–5.0) | 384 (43) | 4.6 (4.3–5.0) | 0.012 |
| 2 h blood glucose (mmol/L) | 149 (56) | 6.4 (5.3–7.6) | 373 (42) | 6.0 (5.2–6.9) | 0.001 |
| Fasting insulin (pmol/L) | 157 (60) | 60 (40–114) | 410 (46) | 53 (36–82) | 0.002 |
| HOMA-ir (pmol mmol/L2) | 152 (58) | 14.8 (9.1–25.9) | 388 (43) | 11.3 (7.6–17.1) | 0.330 |
| Total testosterone (nmol/L) | 170 (64) | 1.7 (1.2–2.3) | 655 (73) | 1.8 (1.3–2.5) | 0.708 |
| SHBG (nmol/L) | 244 (92) | 45 (30–64) | 829 (93) | 44 (31–67) | 0.367 |
| Free testosterone (nmol/L) | 167 (63) | 0.032 (0.021–0.049) | 644 (72) | 0.033 (0.021–0.050) | 0.012 |
| P¤ | |||||
| BMI ≥ 25 kg/m2 | 186 (76) | 469 (56) | < 0.001 | ||
| BMI < 25 kg/m2 | 59 (24) | 362 (44) | |||
| Waist ≥ 88 cm | 94 (71) | 277 (47) | < 0.001 | ||
| Waist < 88 cm | 40 (30) | 310 (53) | |||
| Systolic BP ≥ 130 mmHg | 84 (57) | 205 (33) | < 0.001 | ||
| Systolic BP < 130 mmHg | 64 (43) | 420 (67) | |||
| Diastolic BP ≥ 85 mmHg | 77 (52) | 186 (30) | < 0.001 | ||
| Diastolic BP < 85 mmHg | 71 (48) | 438 (70) | |||
| Triglycerides ≥ 1.7 mmol/L | 63 (34) | 93 (15) | < 0.001 | ||
| Triglycerides < 1.7 mmol/L | 123 (66) | 569 (86) | |||
Data presented as median (Q1–Q3)
BP blood pressure, LDL low density lipoprotein, HDL high density lipoprotein, 2 h 2 hours (during oral glucose tolerance test), HOMA-ir homeostasis model assessment of insulin resistance, SHBG Sex hormone-binding globulin
P#: non-parametric test on the equality of medians
P¤: Chi squared test