Table 5.
Crude and adjusted hazard ratios in PCOS OUH and development of CVD
| CVD | CVD (HT and DL excluded) | |||||
|---|---|---|---|---|---|---|
| Crude HR (95% CI) | n | Age and BMI Adjusted HRa (95% CI) |
Crude HR (95% CI) | n | Age and BMI Adjusted HRa (95% CI) |
|
| Age (years) | 1.1 (1.1; 1.1) P < 0.001 |
1076 | 1.1 (1.1; 1.1) P < 0.001 |
1.1 (1.1; 1.1) P < 0.001 |
1076 | 1.1 (1.1; 1.1) P < 0.001 |
| BMI (kg/m2) | 1.1 (1.0; 1.1) P < 0.001 |
1076 | 1.1 (1.1; 1.1) P < 0.001 |
1.1 (1.0; 1.1) P < 0.001 |
1076 | 1.1 (1.1; 1.1) P < 0.001 |
| Waist (cm) | 1.0 (1.0;1.0) P < 0.001 |
710 | 1.0 (1.0; 1.0) P = 0.02 |
1.0 (1.0;1.0) P = 0.004 |
710 | 1.0 (1.0; 1.1) P = 0.61 |
| Systolic BP (mmHg) | 1.0 (1.0; 1.1) p < 0.001 |
730 | 1.0 (1.0; 1.0) p < 0.001 |
1.0 (1.0; 1.1) P = 0.001 |
730 | 1.0 (1.0; 1.0) P = 0.09 |
| Diastolic BP (mmHg) | 1.1 (1.0; 1.1) P < 0.001 |
729 | 1.0 (1.0; 1.1) P < 0.001 |
1.1 (1.0; 1.1) P < 0.001 |
729 | 1.0 (1.0; 1.1) P = 0.06 |
| LDL (mmol/l) | 1.8 (1.6; 2.1) P < 0.001 |
804 | 1.5 (1.2; 1.7) P < 0.001 |
1.3 (1.0; 1.8) P = 0.06 |
804 | 1.1 (0.7; 1.5) P = 0.78 |
| Cholesterol (mmol/L) | 1.8 (1.6; 2.1) P < 0.001 |
815 | 1.5 (1.3; 1.7) P < 0.001 |
1.4 (1.0; 1.8) P < 0.02 |
815 | 1.1 (0.8; 1.5) P = 0.41 |
| Triglycerides (mmol/L) | 1.7 (1.4; 2.0) P < 0.001 |
805 | 1.5 (1.2; 1.7) P < 0.001 |
1.3 (0.9; 1.8) P = 15 |
805 | 1.1 (0.7; 1.6) P = 0.63 |
| Prolactin (µg/L) | 0.96 (0.9; 1.0) P = 0.02 |
891 | 0.99 (0.95; 1.02) P = 0.61 |
1.0 (0.9; 1.1) P = 0.89 |
891 | 1.0 (1.0; 1.1) P = 0.33 |
| HbA1c (mmol/mol) | 1.0 (1.0; 1.0) P = 0.30 |
525 | 1.0 (1.0; 1.0) P = 0.73 |
1.0 (1.0; 1.0) P = 0.64 |
525 | 1.0 (1.0; 1.0) P = 0.81 |
| Fasting blood glucose (mmol/L) | 1.5 (1.3; 1.8) P < 0.001 |
510 | 1.3 (1.1; 1.5) P = 0.001 |
1.5 (1.2; 2.0) P = 0.001 |
510 | 1.2 (1.0; 1.7) P = 0.15 |
| 2 h blood glucose (mmol/L) | 1.2 (1.1; 1.3) P < 0.001 |
497 | 1.1 (1.1; 1.2) P < 0.001 |
1.2 (1.1; 1.3) P = 0.003 |
497 | 1.1 (1.0; 1.2) P = 0.12 |
| Fasting insulin (pmol/L) | 1.0 (1.0; 1.0) P < 0.001 |
533 | 1.0 (1.0; 1.0) P = 0.007 |
1.0 (1.0; 1.0) P = 0.32 |
533 | 1.0 (1.0; 1.0) P = 0.82 |
| HOMA-ir (µg/L) | 1.0 (1.0; 1.0) P < 0.001 |
509 | 1.0 (1.0; 1.0) P = 0.001 |
1.0 (1.0; 1.0) P = 0.13 |
509 | 1.0 (1.0; 1.0) P = 0.81 |
| Total testosterone (nmol/L) | 0.9 (0.8; 1.1) P = 0.25 |
772 | 1.0 (0.9; 1.2) P = 0.99 |
0.9 (0.7; 1.3) P = 0.72 |
772 | 1.0 (0.8; 1.4) P = 0.89 |
| SHBG (nmol/L) | 1.0 (1.0; 1.0) P = 0.43 |
1000 | 1.0 (1.0; 1.0) P = 0.30 |
1.0 (1.0; 1.0) P = 0.77 |
1000 | 1.0 (1.0; 1.0) P = 0.23 |
| Free testosterone (nmol/L) | 0.75 (0.01; 39.37) P = 0.89 |
759 | 1.9 (0.03; 112.8) P = 0.75 |
0.0 (0.0; 338.2) P = 0.26 |
759 | 0.0 (0.0; 1858.0) P = 0.36 |
Baseline characteristics in PCOS OUH and risk of development of CVD
Hazard ratios are presented for crude models and models corrected for age and BMI
BP blood pressure, LDL low density lipoprotein, HDL high density lipoprotein, 2 h: 2 hours (during oral glucose tolerance test), HOMA-ir homeostasis model assessment of insulin resistance, SHBG: Sex hormone-binding globulin
aExcept age which is adjusted for BMI alone, and BMI which is adjusted for age alone