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. 2018 Jan 16;15(3):3719–3725. doi: 10.3892/ol.2018.7806

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effect of RRM2 downregulation on cervical cancer cell apoptosis. (A) Flow cytometric analysis of HeLa cell apoptosis with RRM2 siRNA and NC siRNA. (B) Quantitative analysis of the apoptosis rate following transfection. (C) Representative blots demonstrating that RRM2 downregulation reduced p-AKT and c-Myc protein expression. The protein expression level of t-AKT, t-ERK and p-ERK were also analysed by western blotting, but no evident changes were observed. *P<0.05. RRM2, ribonucleotide reductase subunit M2; si, small interfering RNA; NC, negative control; p, phosphorylated; t, total; AKT, AKT serine/threonine kinase; ERK, extracellular signal-regulated kinase; c-Myc, Myc proto-oncogene protein.