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. 2018 Feb 16;15(4):5983–5988. doi: 10.3892/ol.2018.8074

Figure 3.

Figure 3.

ADR resistance regulated by VASH1 relies on the AKT signal pathway. (A) Subsequent to overexpressing VASH1 in 143B cells, phosphorylation of AKT and ERK declined. (B) Subsequent to silencing of VASH1 in U-2OS cells, phosphorylation of AKT and ERK increased. (C) AKT inhibitor LY294002 inhibited P-gp expression and (E) ADR resistance in U-2OS cells induced by silencing VASH1 *P<0.05 vs. U-2OS cells with silenced VASH1. ERK inhibitor U0126 exhibited no effect on (D) P-gp expression or (E) ADR resistance in U-2OS cells induced by silencing VASH1. ADR, Adriamycin; VASH, Vasohibin; P-gp, p-glycoprotein; AKT, protein kinase B; ERK, extracellular signal-related kinase.