Table 6.
Analysis of the two-way and three-way interactions between ADRB2, ADRB3 and ADRA2A genes using quantitative multifactor dimensionality reduction for body composition parameters, lipids and glucose.
| Variables | Best model* | Cross-validation training score | Cross-validation testing score | CVC* | p† |
|---|---|---|---|---|---|
| body mass (kg) | Gly16Arg | 1.57 | 0.61 | 9/10 | 0.557 |
| BMI (kg/m2) | Gly16Arg | 2.35 | 1.06 | 9/10 | 0.435 |
| %FM (%) | Gly16Arg,G1780A | 2.45 | -0.75 | 6/10 | 0.875 |
| FFM (kg) | G1780A | 1.18 | -2.29 | 6/10 | 0.995 |
| TBW (kg) | Gly16Arg, Glu27Gln,Trp64Arg | 2.20 | -1.86 | 6/10 | 0.986 |
| TC (mg/dL) | Glu27Gln | 1.81 | 1.91 | 10/10 | 0.213 |
| TGL (mg/dL) | Glu27Gln | 2.11 | -1.56 | 6/10 | 0.969 |
| HDL (mg/dL) | Trp64Arg, G1780A | 3.69 | 3.67 | 10/10 | 0.018 |
| LDL (mg/dL) | Glu27Gln | 1.76 | 0.55 | 7/10 | 0.557 |
| Glucose (mg/dL) | Gly16Arg,Glu27Gln, Trp64Arg | 2.45 | -1.25 | 9/10 | 0.960 |
*ablethe best gene-gene interaction model was determined using cross-validation consistency (CVC) and cross-validation testing score
† permuted p value (1000 permutations)