. Author manuscript; available in PMC: 2018 Mar 9.

Published in final edited form as: J Med Chem. 2016 Jul 22;59(15):7075–7088. doi: 10.1021/acs.jmedchem.5b02038

Table 2.

Biological Activity Data for Hits of Interest

compd	schistosomula EC₅₀ (μM)	adult EC₅₀ (μM)		WSS-1 CC₅₀ (μM)	papain IC₅₀ (μM)
compd	schistosomula EC₅₀ (μM)	male	female	WSS-1 CC₅₀ (μM)	papain IC₅₀ (μM)
1	>20	29.8	5.77	17.48	>100
2	>20	10.2	17.9	133.40	>100
3	3.23	6.43	5.68	16.38	>100
4	2.62	21.1	4.91	28.49	>100
5	>20	ND^a	ND	ND	ND
6	>20	ND	ND	ND	ND
PZQ	1.90	0.22^b	0.64	>400	ND

ND: not determined.

EC₅₀ values produced for adult male after 72 h of exposure. WSS-1 human kidney epithelial cells were used to evaluate cytotoxicity.