Table 1.
Characteristics at baseline of patients in MR CLEAN Registry and MR CLEAN trial (intervention and control arms). Values are numbers (percentages) of participants unless stated otherwise
| Characteristics | MR CLEAN Registry (n=1488) | MR CLEAN | |
|---|---|---|---|
| Intervention arm (n=233) | Control arm (n=267) | ||
| Median (interquartile range) age (years) | 71 (60-80) | 66 (55-76) | 66 (56-76) |
| Men | 794 (53.3) | 135 (57.9) | 157 (58.8) |
| Median (interquartile range) NIHSS score | 16 (11-20) | 17 (14-21) | 18 (14-22) |
| Clinical localisation: left hemisphere | 745 (53.5) | 116 (49.8) | 153 (57.3) |
| Mean (SD) systolic blood pressure (mm Hg) | 150 (25) | 146 (26) | 145 (24) |
| Intravenous alteplase treatment | 1161 (78.0) | 203 (87.1) | 242 (90.6) |
| Medical history: | |||
| Atrial fibrillation | 327 (22.3) | 66 (28.3) | 69 (25.8) |
| Hypertension | 745 (50.7) | 98 (42.1) | 129 (48.3) |
| Diabetes mellitus | 255 (17.2) | 34 (14.6) | 34 (12.7) |
| Myocardial infarction | 228 (15.6) | 33 (14.2) | 42 (15.7) |
| Peripheral artery disease | 135 (9.3) | 8 (3.4) | 16 (6.0) |
| Ischaemic stroke | 249 (16.8) | 29 (12.4) | 25 (9.4) |
| Prestroke modified Rankin Scale score: | |||
| 0 | 991 (67.8) | 190 (81.6) | 214 (80.2) |
| 1 | 189 (12.9) | 21 (9.0) | 29 (10.9) |
| 2 | 110 (7.5) | 12 (4.9) | 13 (5.2) |
| ≥3 | 171 (11.7) | 10 (4.3) | 11 (4.1) |
| Current smoking | 338 (22.9) | 65 (27.9) | 78 (29.2) |
| Drug use: | |||
| Statin | 522 (35.8) | 65 (27.9) | 78 (29.2) |
| Antiplatelet | 493 (33.6) | 64 (27.5) | 80 (30.0) |
| Level of occlusion on non-invasive vessel imaging: | |||
| ICA | 82 (5.7) | 1 (0.4) | 3 (1.1) |
| ICA-T | 313 (22.0) | 59 (25.3) | 75 (28.2) |
| M1 | 825 (58.0) | 154 (66.1) | 165 (62.0) |
| M2 | 175 (12.3) | 18 (7.7) | 21 (7.9) |
| Other* | 27 (1.9) | 1 (0.4) | 2 (0.8) |
| ASPECTS subgroups: | |||
| 0-4 | 93 (6.5) | 10 (4.7) | 19 (7.2) |
| 5-7 | 341 (24.0) | 54 (23.3) | 39 (14.8) |
| 8-10 | 989 (69.5) | 167 (72.0) | 206 (78.0) |
| Collaterals grade: | |||
| 0 | 97 (7.0) | 9 (3.9) | 17 (6.5) |
| 1 | 461 (33.3) | 72 (30.7) | 64 (24.3) |
| 2 | 535 (38.7) | 88 (38.1) | 110 (42.2) |
| 3 | 288 (20.9) | 62 (27.3) | 71 (27.0) |
| Transfer from primary stroke centre | 808 (54.4) | 118 (44.2) | 101 (43.4) |
| Categories after onset of stroke (median (interquartile range)): | |||
| To intravenous alteplase treatment (mins) | 80 (62-120) | 85 (67-110) | 87 (65-116) |
| To intervention centre (mins) | 134 (60-189) | 90 (48-186) | 104 (49-209) |
| To endovascular treatment (mins) | 208 (160-265) | 260 (210-313) | NA |
| Median (interquartile range) to successful reperfusion or last contrast bolus (mins) | 267 (217-331) | 339 (274-395) | NA |
ICA=internal carotid artery; ICA-T=internal carotid artery terminus; M1/M2=middle cerebral artery; NA=not applicable.
*
In nine patients the occlusion location was considered to be in the middle cerebral artery (M2) at the moment endovascular treatment was decided, but the imaging core laboratory observed an M3 occlusion. Six patients had an occlusion in the anterior cerebral artery (A1/A2). Twelve patients underwent endovascular treatment without a definitive occlusion on computed tomography angiography according to the core laboratory.