Table 2. GO categories enriched among genes with NSY SNPs and scored by PROVEAN as severe mutations.

R. mackenziei Strain	GO Category	Term	P-Value	Top Five PFAM Domains
IHM 22877	GO:0016491	Oxidoreductase activity	1.74E−08	PF00106, PF00107, PF08240, PF01266, PF00171
	GO:0055114	Oxidation-reduction process	3.00E−08	PF00067, PF08240, PF00107, PF01266, PF00732
	GO:0042623	ATPase activity, coupled	5.30E−08
	GO:0016887	ATPase activity	7.13E−08	PF00005
	GO:0015399	Primary active transmembrane transporter activity	7.90E−07
	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	7.90E−07
	GO:0043492	ATPase activity, coupled to movement of substances	1.37E−06
	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	2.08E−06	PF00664, PF06422
	GO:0016462	Pyrophosphatase activity	2.43E−06
	GO:0016818	Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4.52E−06
	GO:0016820	Hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	4.57E−06
	GO:0017111	Nucleoside-triphosphatase activity	5.58E−06
	GO:0016817	Hydrolase activity, acting on acid anhydrides	9.17E−06
	GO:0003824	Catalytic activity	2.29E−05	PF00501, PF01048, PF02515, PF00128, PF01557
	GO:0022804	Active transmembrane transporter activity	5.85E−05
	GO:0046906	Tetrapyrrole binding	1.30E−04
	GO:0020037	Heme binding	1.30E−04	PF00067, PF01077, PF00199
	GO:0016705	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1.59E−04	PF00067
dH24460	GO:0016491	Oxidoreductase activity	3.11E−07	PF00106, PF00107, PF08240, PF02668, PF01565
	GO:0055114	Oxidation–reduction process	1.45E−06	PF00067, PF08240, PF00107, PF02668, PF00732
	GO:0016705	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	9.97E−06	PF00067
	GO:0005506	Iron ion binding	4.32E−05	PF00067, PF10637, PF00848

GO, gene ontology; PFAM, protein family database.