Figure 3.

DAF-19 presence downregulates expression of novel target genes in certain nonsensory neurons and ciliated sensory neurons. Expression patterns of transcriptional fusions of daf-19 target gene promoters with GFP in isogenic daf-12(sa204) and daf-19(m86); daf-12(sa204) adult hermaphrodites (N = 30 worms/strain analyzed, except for gakh-1, N = 130). Views are lateral with dorsal at the top and anterior to the left. Neurons in which daf-19-dependent expression was found are identified. Cell bodies in which gene expression is absent in worms wild-type for daf-19 are indicated by dotted circles. Microvilli at the dendritic tips of AFD sensory neurons (in the right skr-12 image) are magnified an additional 2×. Bar, 10 μm.