Table 1. Viability estimates for Slc25a13hspn/hspn and Dlx5+/− Slc25a13+/hspn mice at weaning age.
| Observed number of progeny for each genotype | Expected genotype ratio | Chi square (probability) | Semilethal genotype | ||||
|---|---|---|---|---|---|---|---|
| Expected numbera | Estimated viabilityb (%) | ||||||
| A. Mating: Slc25a13+/hspn × Slc25a13hspn/hspn | |||||||
| Slc25a13hspn/hspn | Slc25a13+/hspn | 1:1 | Slc25a13hspn/hspn | ||||
| Female | 36 | 128 | 51.6 (P < 0.0001) | 128 | 28 | ||
| Male | 57 | 103 | 13.2 (P < 0.005) | 103 | 55 | ||
| B. Mating: Slc25a13+/hspn × Slc25a13+/hspn | |||||||
| Slc25a13hspn/hspn | Slc25a13+/+ or +/hspn | 1:3 | Slc25a13hspn/hspn | ||||
| Female | 21 | 168 | 19.4 (P < 0.0001) | 56 | 38 | ||
| Male | 31 | 182 | 12.4 (P < 0.005) | 60.7 | 51 | ||
| C. Mating: Dlx5+/− × Slc25a13hspn/hspn | |||||||
| Dlx5+/− Slc25a13+/hspn | Dlx5+/+ Slc25a13+/hspn | 1:1 | Dlx5+/KO Slc25a13+/hspn | ||||
| 5 (3 females, 2 males) | 54 (24 females, 30 males) | 40.7 (P < 0.0001) | 54 | 9 | |||
| D. Mating: Dlx5+/− × Dlx5+/+ | |||||||
| Dlx5+/− | Dlx5+/+ | 1:1 | No significant difference | ||||
| 76 | 69 | 0.34 (P > 0.5) | |||||
| E. Mating: Dlx5+/− × Slc25a13−/− | |||||||
| Dlx5+/− Slc25a13+/− | Dlx5+/+ Slc25a13+/− | 1:1 | No significant difference | ||||
| 6 | 6 | 0 (P > 0.9) | |||||
a
Expected number of progeny if no lethality.
b
Observed/expected number × 100.