Table 3.
Multivariable linear regression analysis of the associations between serum folate levels (expressed as per 10 ng/ml decrease) and markers of inflammation, allergy, and measures of pulmonary function.
| Overall | Children with Asthma | Children without Asthma | ||||
|---|---|---|---|---|---|---|
| Unadjusted Beta (95% CI) |
Adjusted Beta* (95% CI) |
Unadjusted Beta (95% CI) |
Adjusted Beta* (95% CI) |
Unadjusted Beta (95% CI) |
Adjusted Beta* (95% CI) |
|
| Pulmonary function | ||||||
| Pre-bronchodilator FEV1 Z-score |
−0.24 [−0.42,−0.07] |
−0.18 [−0.38, 0.02] |
−0.29 [−0.57, −0.02] |
−0.22 [−0.50, 0.05] |
−0.15 [−0.41, 1.06] |
−0.14 [−0.41, 0.14] |
| Pre-bronchodilator FVC Z-score |
−0.09 [−0.27, 0.09] |
−0.08 [−0.28, 0.12] |
−0.09 [−0.37, 0.18] |
−0.04 [−0.31, 0.24] |
−0.17 [−0.44, 0.10] |
−0.16 [−0.44, 0.12] |
| Pre-bronchodilator FEV1/FVC Z-score |
−0.23 [−0.37, −0.08] |
−0.15 [−0.30, 0.00] |
−0.29 [−0.52, −0.06] |
−0.28 [−0.52, −0.05] |
0.01 [−0.16, 0.19] |
0.03 [−0.15, 0.21] |
| Markers of inflammation | ||||||
| FeNO (log scale) |
0.22 [0.10, 0.34] |
0.07 [−0.06, 0.19] |
0.21 [0.02, 0.40] |
0.12 [−0.07, 0.32] |
0.07 [−0.07, 0.22] |
0.01 [−0.15, 0.16] |
| Markers of allergy | ||||||
| Total serum IgE (log scale) | 0.04 [−0.17, 0.24] |
0.01 [−0.21, 0.23] |
−0.05 [−0.32, 0.23] |
0.02 [−0.27, 0.31] |
−0.09 [−0.40, 0.23] |
0.00 [−0.34, 0.34] |
Values in boldface are statistically significant at p<0.05 level
*
Adjusted for age, sex, BMI, SES. Overall also adjusted for asthma status