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. 2017 Jul 21;52(2):244–255. doi: 10.1177/2168479017720249

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 8. — DARS is using hollow fiber culture systems to investigate the factors critical to antibiotic resistance emergence and evaluate treatment strategies to suppress emergent resistance. This in vitro system allows culture of pathogenic bacteria and exposure of those bacteria to single and combination antibiotic treatments to discover the critical elements for evolution of resistance and how to best treat infections to suppress emergent resistance. Results will inform in vivo assessment of antibiotic resistance in mouse models and clinical trials.