Table 3.
Multivariable model predicting HPV-positive oropharyngeal anatomic sites among non-Hispanic black and non-Hispanic white Males (n = 11,267), by HPV Status. National Cancer Database, 2009–2013.
| Adjusted Relative Risk (95%Confidence Interval) | P value | |
|---|---|---|
| Among non-Hispanic white males | <0.0001 | |
| Socioeconomic Status (area-level) tertilesa | ||
| 1st Tertile (Lowest) | 1.00 (reference) | |
| 2nd Tertile | 1.05 (1.01–1.10) | |
| 3rd Tertile (Highest) | 1.11 (1.07–1.15) | |
| Among non-Hispanic black males | <0.0001 | |
| Socioeconomic Status (area-level) tertilesa | ||
| 1st Tertile (Lowest) | 1.00 (reference) | |
| 2nd Tertile | 1.44 (1.18–1.77) | |
| 3rd Tertile (Highest) | 1.76 (1.46–2.12) | |
| Age | <0.0001 | |
| <30 | 0.97 (0.53–1.80) | |
| 30–34 | 1.11 (0.73–1.69) | |
| 35–39 | 1.32 (1.12–1.56) | |
| 40–44 | 1.34 (1.20–1.50) | |
| 45–49 | 1.37 (1.24–1.52) | |
| 50–54 | 1.31 (1.19–1.45) | |
| 55–59 | 1.31 (1.18–1.44) | |
| 60–64 | 1.30 (1.18–1.43) | |
| 65–69 | 1.27 (1.15–1.40) | |
| 70–74 | 1.18 (1.06–1.31) | |
| 75 and above | 1.00 (reference) | |
| Charlson/Deyo comorbidity scoreb | 0.1157 | |
| 0 | 1.00 (reference) | |
| 1–2 | 0.97 (0.93–1.01) | |
| Primary payer at diagnosis | <0.0001 | |
| Private insurance | 1.00 (reference) | |
| Other government | 0.94 (0.86–1.03) | |
| Medicare | 0.89 (0.85–0.94) | |
| Medicaid | 0.75 (0.70–0.80) | |
| Not insured | 0.77 (0.71–0.83) | |
| Insurance status unknown | 0.72 (0.60–0.86) | |
| Rural-Urban continuum, 2003c | 0.0016 | |
| Rurald | 1.00 (reference) | |
| Urbane | 0.91 (0.86–0.96) | |
| Oropharyngeal | <0.0001 | |
| Oropharynx | 1.00 (reference) | |
| Tongue (base) | 1.34 (1.25–1.45) | |
| Tonsil | 1.41 (1.31–1.51) | |
| Year of diagnosisf | 1.07 (1.05–1.08) | <0.0001 |
Area-level composite measure of socioeconomic status divided into thirds at the tertiles of the sample distribution.
Charlson/Deyo Score with values 0 (no comorbid conditions recorded), 1 and 2 (greater than 1).
Area-based measure of rurality and urban influence estimated by matching the state and county FIPS code of the patient recorded at the time of diagnosis against the 2013 typology published by the United States Department of Agriculture Economic Research Service.
Rural designation includes: Urban population of ≥20,000 and not adjacent to a metro area, or completely rural/<2500 urban population and adjacent to a metro area, or completely rural/<2500 urban population and not adjacent to a metro area.
Urban designation includes: Counties in metro areas of ≥1 million population, or counties in metro areas of 250,000–1 million, or counties in metro areas of <250,000, or urban population of ≥20,000 and adjacent to a metro area, or urban population of 2500–19,999 and adjacent to a metro area, or completely rural/<2500 urban population and adjacent to a metro area.
Year of diagnosis modeled continuously.