Table 2. Proportional Hazards Cox Regression Model Predicting the Likelihood of Ischemic Cardiovascular Disease by Des-gamma carboxy Prothrombin.
DCP (quartiles) | ||||||
---|---|---|---|---|---|---|
|
||||||
Events/N | Q1 (0.33-2.40) |
Q2 (2.41-3.47) |
Q3 (3.48-4.63) |
Q4 (4.64-<20.1) |
DCP (continuous) |
|
Model 1 | 75/709 | reference | 1.38 | 1.83 | 1.71 | 1.46 |
(0.62-3.06) | (0.81-4.12) | (0.79-3.70) | (1.08-1.97) | |||
p=0.428 | p=0.143 | p=0.173 | p=0.013 | |||
Model 2 | 74/694 | reference | 1.48 | 1.96 | 2.03 | 1.58 |
(0.62-3.52) | (0.83-4.66) | (0.82-5.04) | (1.13-2.22) | |||
p=0.378 | p=0.126 | p=0.125 | 0.008 | |||
Model 3 | 59/617 | reference | 1.46 | 1.82 | 1.87 | 1.53 |
(0.61-3.50) | (0.78-4.23) | (0.76-4.58) | (1.09-2.13) | |||
p=0.39 | p=0.163 | p=0.171 | 0.013 |
Abbreviation: DCP = des-gamma carboxy Prothrombin; Q = quartile.
Note: Table shows hazard ratio (95% confidence interval). All models are weighted for case-cohort design and use robust standard errors. Model 1: Adjusted for age, gender, and race/ethnicity. Model 2: Adjusted for Model 1 + BMI, cigarette smoking (never, former, current), education (high school graduate), diabetes, systolic blood pressure, antihypertension medication use, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, high-sensitivity C-reactive protein, lipid-lowering medication, estimated glomular filtration rate, albumin and creatinine ratio, intentional physical activity, and current alcohol use. Model 3: Adjusted for Model 2 + phylloquinone, and dihydrophylloquinone.