Table 4.
In vitro antiproliferation activity of regorafenib against vascular and tumor cell lines
| Cell lines | Regorafenib8,14 (IC50 [nM/L]±SD) |
|---|---|
| VEGF165-stimulated HuVECs | 2.6±0.8 |
| FGF2-stimulated HuVECs | 127±13 |
| PDGF-BB-stimulated HAoSMCs | 146±114 |
| VEGFR-2-stimulated HuVECs | 4–16 |
| VEGFR-3-stimulated LECs | 4–16 |
| SW620 (KRASG12V), colon | 967±287 |
| Colo-205, colon | 3269 |
Abbreviations: FGF, fibroblast growth factor; HAoSMCs, human aortic smooth muscle cells; HuVECs, human umbilical vascular endothelial cells; IC50, 50% inhibitory concentration; LECs, lymphatic endothelial cells; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor.