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. 2018 Mar 9;13(3):e0194017. doi: 10.1371/journal.pone.0194017

Fig 8. Non-canonical binding site potency.

Fig 8

Cumulative distributions of average interaction scores for all 7990 miRNA-3’ UTR combinations probed. (A) according to the presence of offset 6mer binding site patterns. Combinations with at least one offset 6mer pattern, have lower interaction scores than combinations without. Distributions are significantly different (one-sided Kolmogorov-Smirnov p-value < 0.001). (B) according to the presence of seed-mismatched or G:U wobble binding site patterns. Combinations with at least one seed-mismatched or G:U wobble pattern have lower interaction scores than combinations without. Distributions are significantly different (one-sided Kolmogorov-Smirnov p-value < 0.01). (C) according to the presence of G-bulge binding site patterns. Combinations with G-bulge patterns don’t have detectably lower interaction scores than combinations without. Distributions are not significantly different (one-sided Kolmogorov-Smirnov p-value > 0.05). (D) according to the presence of offset 6mer binding site patterns with 3’ supplementary pairing. Combinations harboring offset 6mer patterns with 3’ supplementary pairing have lower interaction scores than those without. All distributions are significantly different from one another (one-sided Kolmogorov-Smirnov p-values < 0.001 after Benjamini-Hochberg multiple testing correction). (E) according to the presence of seed-mismatched or G:U wobble binding site patterns with 3’ supplementary pairing. Combinations harboring seed-mismatched or G:U wobble patterns with 3’ supplementary pairing have lower interaction scores than those without. All distributions are significantly different from one another (one-sided Kolmogorov-Smirnov p-values < 0.05 after Benjamini-Hochberg multiple testing correction). (F) according to the presence of G-bulge binding site patterns with 3’ supplementary pairing. Combinations harboring G-bulge patterns with 3’ supplementary pairing have lower interaction scores than those without. All distributions are significantly different from one another (one-sided Kolmogorov-Smirnov p-values < 0.05 after Benjamini-Hochberg multiple testing correction).