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. Author manuscript; available in PMC: 2018 Jun 12.
Published in final edited form as: Nat Biomed Eng. 2017 Dec 12;1:993–1003. doi: 10.1038/s41551-017-0167-9

Figure 5. Passive accumulation of ReANCs, via the discontinuous fenestration architecture of bone tissue, in a metastatic luminal breast cancer model.

Figure 5

Athymic nude mice were injected with MCF7 derived cells via the left ventricle to form metastases in bones followed by weekly injections of ReANC nanoprobes. (a) Representative ventral (supine) images showing SWIR signal from the bone space of tumor-bearing and healthy control animals show significant accumulation of ReANCs in the bone lesions 5 weeks post inoculation. (b) There is significant increase in SWIR emission intensity in bone starting 4 weeks post inoculation in tumor-bearing and healthy controls injected with ReANCs. There was no significant increase in accumulation of fReANC in bones of tumor-bearing and healthy control animals. Data in (b) is expressed as mean±S.D; n=6 for tumor-bearing group and n=3 for healthy control group represented as a fold increase compared to healthy control group.*two-tailed P<0.05 determined using a Welch’s t-test. SWIR intensities were normalized to those of the healthy control groups for the region of interest at each time point.