Fig 1. Relative abundance of anaerobic genera and Shannon diversity in bacterial communities based on patient clinical state and disease stage.

The cumulative relative abundances of anaerobic genera (Actinomyces, Fusobacterium, Gemella, Granulicatella, Porphyromonas, Prevotella, Rothia, Streptococcus and Veillonella spp) are depicted by (A) clinical state and (B) disease stage. Bacterial community Shannon diversity is depicted by (C) clinical state and (D) disease stage. ***P ≤ 0.001 (GEE).