Table 3.
Restricted Mean Survival Time at 10 Years Determined Using Curves Kaplan-Meier and Flexible Parametric Survival Final Model for 321 Men with and without Biochemical Failure Treated by Radical Prostatectomy for Prostate Cancer Followed for 10 Years
| Methodologies | Group A Absence CPC Absence mM n=140 RMST (95% CI) |
Group B Absence CPC Presence mM n=54 RMST (95% CI) |
Group C Presence CPC Absence mM n=39 RMST (95% CI) |
Group D Presence CPC Presence mM n=88 RMST (95% CI) |
p-value two tail a |
|---|---|---|---|---|---|
| Numeric integration | 9.55 | 9.13 | 4.15 | 3.71 | <0.01 |
| (9.27 to 9.84) | (8.73 to 9.54) | (3.28 to 5.02) | (3.14 to 4.28) | ||
| Pseudovalues | 9.46 | 9.11 | 3.91 | 3.56 | <0.01 |
| (9.17 to 9.74) | (8.65 to 9.57) | (3.29 to 4.53) | (3.07 to 4.06) | ||
| Model FP | 9.47 | 9.23 | 4.62 | 3.57 | <0.01 |
| (9.24 to 9.69) | (8.87 to 9.58) | (4.46 to 4.77) | (3.52 to 3.63) |
For determining RMST on curve of Kaplan-Meier, it’s used the methodologies of Numeric integration and pseudovalues; Model FP, indicates determination RMST using flexible parametric survival final model on scale hazard, incorporates the presence of CPC and mM, with four degrees of freedom for baseline hazard function (DF4) and CPC as variable time-dependent effect (TVC) with one degrees of freedom (DFTVC1); RMST, Restricted Mean Survival Time at 10 years;
The one-way analysis of variance; For The Bonferroni correction to adjust for multiple comparisons showed significant difference (p-values<0.01) between groups: A versus C, A versus D, and B versus C and B versus D.