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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Cancer Res. 2017 Nov 1;78(1):278–289. doi: 10.1158/0008-5472.CAN-17-1974

Figure 3. SRH identifies pediatric surgical lesions of the posterior fossa.

Figure 3

Magnetic resonance images (midsagittal T1-weighted post-gadolinium) of the three most common surgical lesions of posterior fossa are shown: pilocytic astrocytoma (A), ependymoma (E), and medulloblastoma (I). Pilocytic astrocytoma SRH shows biphasic pattern (black dashed line, B) with protein-rich pilocytic processes (C) and Rosenthal fibers (D). Ependymomas demonstrate rosette formation (F) and pseudorosette formation shown in cross-section (G) and longitudinal section (H). Medulloblastomas are densely hypercellular on low- (J) and high-magnification (K). Homer-Wright rosette formation (L) is visualized throughout the SRH mosaic. Scale bars are 100 μm in large tiles, 50 μm in small tiles.