Table 1. List of up-regulated and down-regulated mRNAs detected using RNA-seq (FC ≥ 2.83, P < 0.05).
| Gene Name | log2(Tum/Ctr) | up-or-down | P_value | Description |
|---|---|---|---|---|
| MPO | –6.18461 | down | 0.00635 | myeloperoxidase |
| MAGEB2 | –5.44166 | down | 0.0158 | MAGE family member B2 |
| CD8A | –3.35204 | down | 0.00275 | CD8a molecule |
| BPI | –3.31652 | down | 0.0279 | bactericidal/permeability-increasing protein |
| PGLYRP1 | –3.3111 | down | 0.0412 | peptidoglycan recognition protein 1 |
| LOC283788 | –3.17651 | down | 0.0005 | FSHD region gene 1 pseudogene |
| IL18R1 | –3.02589 | down | 5.00E-05 | interleukin 18 receptor 1 |
| ADCYAP1 | –2.96929 | down | 0.031 | adenylate cyclase activating polypeptide 1 |
| CXCL13 | –2.90547 | down | 0.02165 | C-X-C motif chemokine ligand 13 |
| MS4A1 | –2.78553 | down | 0.013 | membrane spanning 4-domains A1 |
| SERPINB4 | –2.67117 | down | 0.02235 | serpin family B member 4 |
| MMP12 | –2.65413 | down | 0.02265 | matrix metallopeptidase 12 |
| PIP | –2.63046 | down | 0.00195 | prolactin induced protein |
| LEFTY2 | –2.59114 | down | 0.0361 | left-right determination factor 2 |
| IL13RA2 | –2.54593 | down | 0.04385 | interleukin 13 receptor subunit alpha 2 |
| CSMD3 | –2.54162 | down | 0.00145 | CUB and Sushi multiple domains 3 |
| OR51E1 | –2.45263 | down | 0.0003 | olfactory receptor family 51 subfamily E member 1 |
| PTH2R | –2.32814 | down | 0.03325 | parathyroid hormone 2 receptor |
| ADRB3 | –2.30562 | down | 0.0493 | adrenoceptor beta 3 |
| CCL4L2 | –2.18575 | down | 0.01295 | C-C motif chemokine ligand 4 like 2 |
| ERAP2 | –2.14489 | down | 5.00E-05 | endoplasmic reticulum aminopeptidase 2 |
| LTF | –2.14431 | down | 0.00755 | lactotransferrin |
| PADI4 | –2.08682 | down | 0.0333 | peptidyl arginine deiminase 4 |
| OR51E2 | –2.0297 | down | 0.01705 | olfactory receptor family 51 subfamily E member 2 |
| FKBP5 | –1.98625 | down | 0.00045 | FK506 binding protein 5 |
| FOLH1 | –1.97677 | down | 0.0032 | folate hydrolase (prostate-specific membrane antigen) 1 |
| CD3G | –1.862 | down | 0.04425 | CD3g molecule |
| COL6A5 | –1.72947 | down | 0.0316 | collagen type VI alpha 5 |
| TUBBP5 | –1.70945 | down | 0.0228 | tubulin beta pseudogene 5 |
| CLEC4M | –1.6691 | down | 0.0217 | C-type lectin domain family 4 member M |
| S100A9 | –1.66717 | down | 0.0021 | S100 calcium binding protein A9 |
| DIO3 | –1.65761 | down | 0.009 | deiodinase, iodothyronine, type III |
| LOC645752 | –1.64348 | down | 0.0449 | golgin A6 family member A pseudogene |
| CD3E | –1.61303 | down | 0.0266 | CD3e molecule |
| TNNT3 | –1.55491 | down | 0.00495 | troponin T3, fast skeletal type |
| S100A8 | –1.53696 | down | 0.0022 | S100 calcium binding protein A8 |
| FUT9 | –1.50479 | down | 0.00195 | fucosyltransferase 9 |
| KRT31 | 1.50307 | up | 0.02565 | keratin 31 |
| KRTAP11-1 | 1.51562 | up | 0.00975 | keratin associated protein 11-1 |
| KRT85 | 1.51808 | up | 0.01765 | keratin 85 |
| KRT81 | 1.54671 | up | 0.0292 | keratin 81 |
| KRT34 | 1.54769 | up | 0.03615 | keratin 34 |
| EPSTI1 | 1.574 | up | 0.0017 | epithelial stromal interaction 1 (breast) |
| IFI6 | 1.57562 | up | 0.0033 | interferon alpha inducible protein 6 |
| IFI35 | 1.59026 | up | 0.0059 | interferon induced protein 35 |
| KRTAP3-2 | 1.61219 | up | 0.0107 | keratin associated protein 3-2 |
| KC6 | 1.62074 | up | 0.0318 | keratoconus gene 6 |
| KRT83 | 1.65762 | up | 0.0203 | keratin 83 |
| OAS3 | 1.69667 | up | 0.00105 | 2'-5'-oligoadenylate synthetase 3 |
| USP18 | 1.72046 | up | 0.00215 | ubiquitin specific peptidase 18 |
| CYP26B1 | 1.74162 | up | 0.00045 | cytochrome P450 family 26 subfamily B member 1 |
| LNX1-AS2 | 1.74788 | up | 0.022 | LNX1 antisense RNA 2 |
| IFI44 | 1.75064 | up | 0.00015 | interferon induced protein 44 |
| TNFRSF4 | 1.75918 | up | 0.0375 | tumor necrosis factor receptor superfamily member 4 |
| LOC339975 | 1.76055 | up | 0.02065 | uncharacterized LOC339975 |
| CLDN11 | 1.7733 | up | 0.012 | claudin 11 |
| KRT35 | 1.78149 | up | 0.0024 | keratin 35 |
| KRT33A | 1.80012 | up | 0.00445 | keratin 33A |
| OAS2 | 1.83729 | up | 0.00145 | 2'-5'-oligoadenylate synthetase 2 |
| KRT86 | 1.85155 | up | 0.0094 | keratin 86 |
| DCD | 1.85338 | up | 0.0401 | dermcidin |
| ACAN | 1.85416 | up | 0.0002 | aggrecan |
| PKD1L2 | 1.90338 | up | 0.0378 | polycystin 1 like 2 (gene/pseudogene) |
| SCGB1B2P | 1.91013 | up | 0.01375 | secretoglobin family 1B member 2, pseudogene |
| CMPK2 | 1.92066 | up | 0.00015 | cytidine/uridine monophosphate kinase 2 |
| ADAMTS18 | 1.95193 | up | 0.0003 | ADAM metallopeptidase with thrombospondin type 1 motif 18 |
| KRT33B | 1.9594 | up | 0.0128 | keratin 33B |
| IFIT1 | 1.97285 | up | 0.0001 | interferon induced protein with tetratricopeptide repeats 1 |
| MX1 | 1.99777 | up | 0.00015 | MX dynamin like GTPase 1 |
| RSAD2 | 2.07171 | up | 5.00E-05 | radical S-adenosyl methionine domain containing 2 |
| IFI44L | 2.31465 | up | 5.00E-05 | interferon induced protein 44 like |
| LINC00487 | 2.42803 | up | 0.0367 | long intergenic non-protein coding RNA 487 |
| ISG15 | 2.47094 | up | 5.00E-05 | ISG15 ubiquitin-like modifier |
| SULT1A2 | 2.52975 | up | 0.02025 | sulfotransferase family 1A member 2 |
| DMC1 | 2.61725 | down | 0.00415 | DNA meiotic recombinase 1 |
| FAM132B | 2.69101 | up | 0.0118 | - |
| NRIR | 2.97361 | up | 0.0399 | negative regulator of interferon response (non-protein coding) |
| MTHFD2P1 | 3.49824 | up | 0.01845 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 1 |
| OR8B2 | 4.67189 | up | 0.0423 | olfactory receptor family 8 subfamily B member 2 |
| LOC101929128 | 4.88337 | up | 0.0419 | uncharacterized LOC101929128 |
Ctr, matched normal skin tissue; Tum, infantile hemangioma skin tissue.