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. 2018 Jan 30;9(15):12137–12153. doi: 10.18632/oncotarget.24343

Figure 9. Overdose of rasagiline and idebenone in combination fails to protect the retina against RIR injury.

Figure 9

(A) Western blot analysis for Bcl-2/Bax ratios and activated caspase-3 levels in IR-injured retinas after administration with overdose of rasagiline and idebenone. (B) Densitometric analysis of Bcl-2/Bax ratios in IR-injured retinas after administration with overdose of rasagiline and idebenone. (C) Densitometric analysis of expression of activated caspase-3 in IR-injured retinas after administration with overdose of rasagiline and idebenone. (D) The percentage of activated caspase-3-positive cells (red) in GCLs of IR-injured retinas after treatment with overdose of rasagiline and idebenone in combination. (E) Analysis of retinal thickness of IR-injured retinas by HE staining after treatment with overdoses of rasagiline and idebenone. (F) Analysis of the survival of RGCs in IR-injured retinas by Tuj1 immunostaining on retinal flat mounting after administration with overdose of rasagiline and idebenone. (G) Photopic visual acuity of RIR-injured mice treated with overdosed rasagiline and idebenone. (H) Percent time spent in the light chamber by RIR-injured mice after overdosed administrations of rasagiline and idebenone. n = 8, ###p < 0.001, ####p < 0.0001, versus control; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, versus vehicle; ns: no significance.