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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Adv Drug Deliv Rev. 2017 Sep 9;125:94–101. doi: 10.1016/j.addr.2017.09.002

Figure 4.

Figure 4

Microrockets for capture and isolation of cancer cells. (A) Upon encountering the cells, the anti-carcinoembryonic antigen (CEA)-modified micromotors recognize the CEA surface antigens on the target cancer cells, allowing their selective pickup and transport. The top-right and bottom-left insets illustrate the preparation of the antibody-modified micromotors and their functionalization, respectively. (B) Isolation of a CEA+ cell in a mixture of cells. The overlay images show sequential steps (1–5) of movement of the anti-CEA mAb-modified micromotor in a mixture of CEA+ and CEA- cells (solid and dotted parentheses, respectively). For clear visualization, step 5 has been slightly displaced. (Reprinted with permission from Ref 69. Copyright 2011)