Fig. 5.

GOF mutant p53 inhibits AMPK-mediated phosphorylation and nuclear localization of FOXO3a. a–d Western blot analyses of isogenic UM-SCC-1, Detroit 562, TR146 and Ca9-22 stable cell lines in the presence or absence of metabolic stress under the confluent high-density culture condition. e Representative images of IHC staining of FOXO3a in mouse tongue tumors derived from UM-SCC-1 stable cell lines. f Quantitation of FOXO3a nuclear staining of e. **p < 0.01